The structures of human and mouse FAM20C.

FAM20C and its substrates in multiple cancers.

The roles of FAM20C in multiple cancers.

A new review published in Genes & Diseases explores the multifaceted role of FAM20C, a Golgi protein kinase, in disease progression.

SHANNON, CLARE, IRELAND, February 23, 2025 /EINPresswire.com/ -- A new review published in Genes & Diseases explores the multifaceted role of FAM20C, a Golgi protein kinase, in disease progression. By highlighting FAM20C’s involvement in cancer growth, biomineralization, cardiovascular diseases, and metabolic disorders, these findings provide promising insights into new therapeutic strategies targeting FAM20C-related pathways.
FAM20C is known for its ability to phosphorylate secreted proteins, regulating critical biological processes. FAM20C is a significant driver of cancer progression, particularly in glioma and breast cancer, by enhancing tumor invasion and metastasis. Additionally, FAM20C’s role in modifying the tumor microenvironment may influence immune cell activation and contribute to cancer aggressiveness.
Beyond oncology, the article underscores FAM20C’s involvement in bone and dental health, linking it to diseases such as Raine syndrome and hypophosphatemic rickets. Furthermore, the authors connect FAM20C to cardiovascular health, demonstrating its influence on vascular calcification and calcium homeostasis in heart function.
The ability of FAM20C to regulate multiple physiological and pathological processes makes it a promising target for future therapeutic development.
The article also explores potential FAM20C inhibitors as new treatment avenues for aggressive cancers such as glioblastoma and triple-negative breast cancer. Experimental data suggest that small-molecule inhibitors targeting FAM20C could reduce tumor growth and metastasis.
Given its diverse biological roles, the identification of FAM20C as a central regulator of disease progression paves the way for innovative treatment strategies across multiple medical fields.

Reference
Rui Zhang, Yanming Ren, Yan Ju, Yuekang Zhang, Yan Zhang, Yuan Wang, FAM20C: A key protein kinase in multiple diseases, Genes & Diseases, Volume 12, Issue 2, 2025, 101179. https://doi.org/10.1016/j.gendis.2023.101179

Funding Information:
National Key Research and Development Program of China, Stem Cell and Translational Research (2022YFA1105200)
National Natural Science Foundation of China (82273117)
Sichuan Science and Technology Program (23ZYZYTS0150)
National Natural Science Foundation of China (82173179)
National Clinical Research Center for Geriatrics (Z2021JC006)
National Natural Science Foundation of China (82302627)
Science and Technology Supportive Project of Sichuan Province (2022YFS0143)
Science and Technology Supportive Project of Sichuan Province (2022YFS0049)

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