Lyophilization is a form of freeze-drying that makes materials easier to transport or increases their shelf life – by as long as four years. Lyophilization is especially useful in the pharmaceutical industry as it stabilizes complex drugs not in liquid state. Lyophilization stabilizes dry powders along with products making it invaluable for drugmakers. The ever-increasing need to increase the shelf life of lifesaving drugs and vaccines is driving the demand for lyophilization equipment in the food & beverage, packaging, and pharmaceutical production industry, benefiting the overall lyophilization equipment market.

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Focus on Peptide Segment for Maximum Profitability in Lyophilization Equipment Market

Lyophilization has become critical to the pharma industry for protein, monoclonal antibodies, peptide, enzymes, oligonucleotide, and enzymes. Statistics suggest that a third of biologic drugs and a sixth of the top 100 pharmaceutical drugs are lyophilized. It is estimated that half of the injectable drugs will soon require lyophilization with double-digit growth a noticeable trend in biopharmaceutical contract manufacturers. Significant growth rates have been recorded in peptides and oligonucleotides that rapidly degrade whilst in liquid form and necessitate lyophilization equipment to boost their shelf-life and stability. Conversely, other branches of the biotechnology sector such as food, environmental, and agricultural biotech are witnessing growth rates decline resulting in immense scope for lyophilization equipment manufacturers during the forecast period.

Conventional Refrigeration Requirements Make Lyophilized Vaccines a Gamechanger

The COVID-19 outbreak has led to unprecedented demand for antibody-drug conjugates (ADC) and monoclonal antibody therapies (mAbs). mRNA vaccines need ultra-cold storage facilities for both storage as well as transportation while lyophilized vaccines only require conventional refrigeration. In April 2021, Pfizer began a clinical trial with a lyophilized formulation for adults in the US and even Russia is considering freeze-drying its Sputnik V vaccine.

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High Cost of Freeze Drying Makes Adoption of Lyophilization Equipment a Challenge

A typical lyophilizer includes a drying chamber and ice condenser to minimize cross-contamination. Lyophilization equipment allows simultaneous loading and defrosting in order to standardize process flows. Safety alarms and interlock automation, refrigeration systems, and vacuum pumps are anticipated to directly contribute to demand in the lyophilization equipment market. Nonetheless, certain challenges must be overcome immediately in the lyophilization equipment market. The termination cost of an unoptimized lyophilization is cost, energy, and time intensive. The cost of freeze drying can run into millions of dollars making it the most expensive component of the production process. In 2019, SP Scientific released a line-of-sight enabled lyophilizer control system termed Lyos 2.0 that is able to control platforms ranging from development to production units. Increasing R&D budgets to fast-track the development of novel drugs is a sure shot way of achieving success in the lyophilization equipment market.

Companies Profiled

Argonaut Manufacturing Services, a biopharma and molecular diagnostics CMO recently expanded its Good Manufacturing Practices facility in Carlsbad, California. Other companies actively involved in the lyophilization equipment market include Azbil Corporation, Industria Macchine Automatiche S.P.A, SP Industries, Inc., GEA Group, Tofflon Science and Technology Co. Ltd., Martin Christ Gefriertrocknungsanlagen GmbH, Labconco Corporation, Hof Enterprise Group, Millrock Technology Inc., Telstar, Labconco, Scala Scientific, and Optima Packaging Group GmbH.

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